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However, there is sometimes a role for non-operative management of full-thickness ruptures in patients who are not highly active or in those who are poor candidates for surgery

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She adds, these symptoms are made worse by an enhanced production of IL-6 in response to pain

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For the BBB in vitro model, mouse BALB/c brain endothelioma cell line b.End3 was used (CRL.2299, ATCC)