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Verdict: Go (for premium/professional segments)

doi: 10.1016/j.eururo.2021.01.014 40 Mateo-OteroYLlavaneraMTorres-GarridoMYesteM

When low glutathione levels, the free radicals can damage the brain cells and lead to cell death

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MLN4924 induces cell death due to uncontrolled DNA synthesis during S-phase of the cell cycle, leading to DNA damage and induction of apoptosis, suggesting that proliferating tumor cells are more susceptible to NAE inhibition 18