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This process is particularly relevant for optimising the use of energy stores and managing muscle fatigue during high-intensity or long-duration training

Establishment of a membrane contact site (MCS) between GLP-1R-positive endosomes and ERMCS-localised VAPB leads to the generation of a pool of highly-localised cAMP and PKA activity that triggers the PKA-dependent phosphorylation of the mitochondrial contact site and cristae organising system (MICOS) complex component MIC19, as well as GLP-1RA-induced mitochondrial remodelling, resulting in improved -cell mitochondrial function and contributing to the potentiation of insulin secretion and survival to ER stress afforded by the GLP-1R

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There is no specific interaction between antacids and Wegovy listed in the UK Summary of Product Characteristics (SmPC)