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The secondary outcomes included GLP1-RA-related adverse events as well as the prevalence of obesity-related comorbidities (dyslipidemia, hypertension and T2D) at baseline and at 6 and 12 months after treatment initiation

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The practical significance: aging brains accumulate proNGF while losing TrkA receptors, creating a biochemical environment that favors neuronal death over survival

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In April 2023, the thrombin inhibitor Argatroban concluded a Phase IV clinical trial in IS (NCT03740958) and was found to significantly reduce adverse prognosis when used in combination with Aspirin (Peng, 2023)

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