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In a recent meta-analysis of 12 observational studies of patients with T2DM treated with either SGLT2 inhibitors or GLP-1RAs, the GLP-1RA group exhibited a significantly lower relative risk of lower limb amputation vs the SGLT2 inhibitor cohort (3.54 vs 4.72 events per 1000 patient-years).37 Furthermore, in the CANVAS program involving 10,142 patients with T2DM at high cardiovascular risk, canagliflozin was found to be associated with a 1.97-fold increased risk of lower-limb amputations

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For most patients with significant midlife hair changes, I still address the underlying hormonal picture, iron and ferritin status, thyroid function, and consider standard therapies like minoxidil and the appropriate use of hormone therapy first

Here's what the evidence actually says, and what it might mean for people living with type 2 diabetes

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