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To provide different perspectives on the estimated treatment effect in weight management RCTs, we recommend that future publications investigating new or already-approved weight-loss medications report the treatment policy estimand and the trial product estimand

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[1] FDA is aware that some compounders incorporate additional ingredients, such as cyanocobalamin (Vitamin B-12), pyridoxine (Vitamin B-6), levocarnitine (L-Carnitine) and nicotinamide adenine dinucleotide (NAD), into their semaglutide products

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Instead, the agency issued guidance clarifying that 503A compounding pharmacies may prepare semaglutide under federal and state oversight

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however, providers were given advanced notice of this planned increase as outlined in the 2024 QCP Manual and communicated throughout the year

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