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As with PGE 2 , the endogenous expression and production of mPGES-1 were low, and IL-1 elicited a 5- and 2.3-fold increase (p 0.05) in levels of mRNA and protein, respectively

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conversely, the genes that exhibited altered expression in mog-3(-) mutant did not display a similar enrichment for DAF-16 motifs (Supplementary Data 7)