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Research to identify predictors of who benefits most from each treatment will further guide individualized care. Ultimately, while some have suggested that potent GLP-1 therapies might replace surgery, our findings demonstrate substantial added benefits including a survival advantage from metabolic surgery even in the era of GLP-1 medicines, he added

doi: 10.1038/s41467-017-02488-y

16 Berenbaum hypothesized that the therapeutic potential of GLP-1 in OA may arise from targeting the crosstalk between macrophages and fibroblasts, which are known to drive inflammation, fibrosis, and downstream cartilage damage

Per a 2024 Marketdata report, tirzepatide is on track to become a best-selling drug, with projected sales hitting $36.5 billion by 2025

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