There have been postmarketing reports of fatal events of ketoacidosis in patients with type 2 diabetes mellitus using SGLT2 inhibitors, including SYNJARDY or SYNJARDY XR
Patients should be advised of the signs and symptoms associated with serotonin syndrome that may include mental status changes (e.g., agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular changes (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea)
This can include unusual injection-site irritation, allergic-type reactions, or immune reactions that do not normally happen with your prescribed dose
SAM and SAH These markers help clarify methyl-donor capacity and inhibition of methyltransferase reactions
But the questions surrounding dosing, cycling, neurological effects, and angiogenic risk are genuinely unresolved
it's a complex issue affecting many aspects of health