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Reduced potency on top of metabolic adaptation creates a double barrier to continued progress
8 5FU sensitisers map to multiple metabolic pathways
Lipid accumulation in skeletal muscle can contribute to insulin resistance, whereas in cardiac muscle, it can cause apoptotic cell death
Explosive market growth for weight-loss medications The GLP-1 market is booming: $26 billion in sales in 2024, projected to hit $100470 billion annually by 2032, dominated by just two pharmaceutical giants: Novo Nordisk and Eli Lilly
5.2 Challenges encountered in clinical studies After a drug has gone through the preclinical phase of experimentation, the drug needs to be tested in clinical trials (Moujalled et al., 2021
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