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This suggests that there might be different lipid metabolic pathways in the two subtypes of HF, and inhibiting myocardial energy deficiency, by restoring ATP-dependent LV relaxation and contraction, might cause beneficial effects in HFpEF [7]
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Unlike native -MSH, MT-2 is a superpotent, non-selective agonist across the melanocortin receptor subtypes, which has made it a widely used tool compound in melanocortin-system research
Biochem Mol Med