Mindbreak Trap will perfectly deal with a creature spell, exiling it from the stack
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Removal is often quite mana-efficient
A cards Lore, Strength, Willpower, or Move cost cant go below 0
You dont have to worry about tapping/untapping things in this game
My first instinct was Dream Devourer in some clunky two-card combo deck in Pioneer or Historic equivalent to Moderns Ad Nauseam plus Angels Grace, especially since an 0/3 creature doesnt have to deal with Lightning Bolt in either format, but I dont know if something to that effect exists